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We now have previously noticed that omalizumab can kind secure ternary complexes with FcεRIα-bound IgE-Fc3–four fragments devoid of eliminating them in the receptor25,forty one. That is because of the exposure of among the omalizumab epitopes that is buried by Cε2 domains inside the intact IgE. We as a result assessed no matter if ligelizumab displays comparable binding conduct working with SPR. IgE-Fc3–four was pre-complexed with immobilized FcεRIα and ligelizumab IgG was subsequently extra.
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